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Advice on Outlook 2016, Exchange Online and best operating practices?

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I'll try and keep this as succinct as possible, waffle mode: engaged...

I've recently started a new role at a what I'd deem a medium sized business, there are ~170 client machines and the better part of a dozen servers, virtual and physical. Client machines are almost exclusively Windows 10 and we use Office 2016 and Exchange Online. The business is quite unique and operates in a fairly complicated way internally.

My issue is this, many of my users are experiencing severe degradation in the performance of their Outlook clients, it hangs/locks and sometimes actually outright errors with warnings over lack of memory. I know the basic root cause; the unimaginable spider web of mailboxes, theirpermissions and shared mailboxes. Some users have up to a dozen mailboxes in their Outlook client, these range from generalised inbound business...


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