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Office 365 Email Issue

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Hi not real sure whats going on but besides email at our main office we also have a server at a remote data center that sends email up to Office 365.  Its from a web app and the email is relayed via script to Office 365 for delivery.  The issue is when we send a bunch of email out at the same time the app gets this error message from Office 365 

 451 4.7.500 Server busy. Please try again later. (AS780081)

Any clues?  Thanks!


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